Fzd3 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comFzd3 Polyclonal Antibody for Mouse(Mus musculus)

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Fzd3 (Gene name),

Frizzled-3 (Protein name ), FZD3_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Fzd3;

Protein name:

Frizzled-3(Fz-3;mFz3);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with VANGL2.

Function:

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism.

Subcellular Location:

Membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

666

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

666:

HGTSMNRVIE | EDGTSA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q61086

UniGene:

Mm.214687

Pfam:

PF01534

String:

Q61086

KEGG:

mmu:14365

Uniprot:

Q61086

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ELISA Kit for Mouse Fz-3

Cat.:

E11111h

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Manual:

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MSDS:

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Packing:

96T

Range:

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ELISA Kit for Mouse Fz-3

MSDS:

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ELISA Kit for Mouse Fz-3

Cat.:

E11111m

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Packing:

96T

CLIA Kit for Mouse Fz-3

Cat.:

U11111m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Fz-3

MSDS:

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CLIA Kit for Mouse Fz-3

Cat.:

U11111h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Fz-3

Cat.:

P11111Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Fz-3

Monoclonal Antibody for Mouse Fz-3

Protein for Mouse Fz-3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled."
Wang Y. , Macke J.P. , Abella B.S. , Andreasson K. , Worley P. , Gilbert D.J. , Copeland N.G. , Jenkins N.A. , Nathans J.
J. Biol. Chem.271:4468-4476(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
2.

"Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner."
Sheldahl L.C. , Park M. , Malbon C.C. , Moon R.T.
Curr. Biol.9:695-698(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: WNT-MEDIATED PKC ACTIVATION
3.

"Characterization of mouse frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes."
Hung B.S. , Wang X.-Q. , Cam G.R. , Rothnagel J.A.
J. Invest. Dermatol.116:940-946(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
4.

"Frizzled-3 is required for the development of major fiber tracts in the rostral CNS."
Wang Y. , Thekdi N. , Smallwood P.M. , Macke J.P. , Nathans J.
J. Neurosci.22:8563-8573(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
5.

"Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling."
Lyuksyutova A.I. , Lu C.C. , Milanesio N. , King L.A. , Gu o N. , Wang Y. , Nathans J. , Tessier-Lavigne M. , Zou Y.
Science302:1984-1988(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;DEVELOPMENTAL STAGE
6.

"Axonal growth and guidance defects in Frizzled3 knock-out mice: a comparison of diffusion tensor magnetic resonance imaging, neurofilament staining, and genetically directed cell labeling."
Wang Y. , Zhang J. , Mori S. , Nathans J.
J. Neurosci.26:355-364(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells."
Wang Y. , Guo N. , Nathans J.
J. Neurosci.26:2147-2156(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
8.

"Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals."
Montcouquiol M. , Sans N. , Huss D. , Kach J. , Dickman J.D. , Forge A. , Rachel R.A. , Copeland N.G. , Jenkins N.A. , Bogani D. , Murdoch J. , Warchol M.E. , Wenthold R.J. , Kelley M.W.
J. Neurosci.26:5265-5275(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VANGL2
9.

"Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development."
Armstrong A. , Ryu Y.K. , Chieco D. , Kuruvilla R.
J. Neurosci.31:2371-2381(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;DEVELOPMENTAL STAGE
10.

"Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons."
Hua Z.L. , Smallwood P.M. , Nathans J.
Elife2:E01482-E01482(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;CONDITIONAL KNOCKOUTS
11.

"Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system."
Hua Z.L. , Jeon S. , Caterina M.J. , Nathans J.
Proc. Natl. Acad. Sci. U.S.A.111:E3005-E3005(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;CONDITIONAL KNOCKOUTS

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